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The primary objective was to determine whether dapagliflozin 10 mg reduces the incidence of the composite endpoint of 50% sustained decline in eGFR, progression to end-stage kidney disease (ESKD) (defined as sustained eGFR 40% and evidence of structural heart disease to determine whether dapagliflozin reduces the risk of cardiovascular death, hospitalization for heart failure or urgent heart failure visits

The hope is that a GLP-1 receptor agonist (or any other anti-obesity medication) could replace medications for a variety of weight-related comorbidities, she said

The risk of incident atrial fibrillation in patients with type 2 diabetes treated with sodium glucose cotransporter-2 inhibitors, glucagon-like peptide-1 receptor agonists, and dipeptidyl peptidase-4 inhibitors: a nationwide cohort study

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Heart Lung Circ 27(1):921 Castiglione V et al (2023) Pathophysiological rationale and clinical evidence for neurohormonal modulation in heart failure with preserved ejection fraction