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Starting retatrutide at full maintenance doses after being on high-dose tirzepatide can lead to excessive GI side effects because of the additional glucagon receptor stimulation

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However, there are some caveats to this study : A case study only observes a single person, and weight loss results often vary from person to person

And GLP-1 medications produce rapid, substantial weight reduction, with clinical trial participants losing an average of 13.6 kg on semaglutide and up to 25% body weight in the SURMOUNT 3 tirzepatide trial

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