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NEW ORLEANS Once-daily orforglipron induced greater reductions in HbA1c than dapagliflozin and oral semaglutide for adults with type 2 diabetes, according to findings from the ACHIEVE-2 and ACHIEVE-3 trials

Compared with placebo (7.8%), relative muscle strength (strength normalized to body weight) was higher with exercise (0.4%), liraglutide (+1.0%), and the combined treatment (+3.3%) because of lower weight and preserved absolute strength

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In summary, a deeper understanding of the physiological and pathological roles of LDs in different organs may offer targeted and integrated treatment options for T2DM and its associated complications.