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Several theories exist about why tirzepatide might contribute to anxiety symptoms in certain individuals: Blood Sugar Fluctuations: Rapid changes in blood glucose levels can trigger symptoms like shakiness, sweating, and nervousness, which can mimic or exacerbate anxiety
Why does GCGR addition matter?# The glucagon receptor, historically viewed as a counter-regulatory target opposing insulin, has a second role as a driver of resting energy expenditure and hepatic lipid handling

Preclinical evidence: GIP may protect bone, supporting a favorable turnover balance

PubMed, Vrang, Niels, et al
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[1] [11] Tirzepatide is not recommended during pregnancy and should be discontinued at least 1 month before a planned pregnancy
