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Description

Cirincione, B., Mager, D.E

GLP-1 receptor agonists have been shown in multiple studies to exert anti-inflammatory effects, including inhibition of monocyte chemotaxis, suppression of macrophage inflammatory responses, and AMPK-mediated downregulation of the NF-B signaling pathway, thereby reducing systemic inflammation (36)

Neuro-humoral actions include modulation of hypothalamic appetite centers, leading to increased satiety and reduced caloric intake, as well as slowing of gastric emptying, which further contributes to appetite suppression and glycemic control [74]

Major Market Trends Rapid adoption of GLP-1 receptor agonists as first-line obesity treatments due to strong real-world weight-loss outcomes

Patients on a GLP-1 receptor agonist were identified as users of this medication for more than 6 months and 2 refills within 6 months before the procedure