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She had been struggling with rapid, unintentional weight loss, excessive sweating, and a persistent tremor in her hands

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People on GLP-1 medications frequently report that alcohol affects them more quickly and more intensely than it did before. The leading explanation is straightforward: GLP-1 medications slow gastric emptying, which means alcohol moves from your stomach into your small intestine more slowly, altering the rate at which it's absorbed into your bloodstream. The practical implication is that a drink you'd have handled comfortably before treatment may hit differently now

It is important to note that orlistat can reduce levothyroxine absorption, and the BNF recommends separating administration by at least 4 hours and monitoring thyroid function

Decreases glucagon secretion when blood glucose is high, which inhibits the liver's glucose output