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Gastroparesis, a condition in which the stomach empties food too slowly, worsens significantly with GLP-1 medications because these drugs slow gastric motility as part of their mechanism

a classical experiment involving damaging a small part of the brain (In technical jargon, a bilateral Ventromedial hypothalamic lesion) caused rats to become morbidly obese (Pictured to the right)

Recognition of Healthcare Burden: There is an ever-increasing awareness that treating obesity results in meaningful improvement in cardiovascular outcomes and lowers the risk of developing multiple related cardiometabolic diseases including Type 2 Diabetes Mellitus (T2DM), chronic kidney disease (CKD), heart failure, fatty liver or MASH, obstructive sleep apnea (OSA), and peripheral arterial disease (PAD), moving the needle beyond aesthetics and towards total health improvement

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With current research, activation of these receptors has overall reduced caloric intake and increased energy expenditure, successfully leading to higher weight loss compared to alternative treatments

Cardiovascular Protection Smoking, being overweight or obese, diabetes, dyslipidemia, and hypertension are all recognized cardiovascular risk factors [19]