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With guidance from healthcare professionals, many people quickly become comfortable using them

Where semaglutide activates only GLP-1 receptors, tirzepatide activates both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors

Intra-islet glucagon, acting through the beta cell GLP-1R and glucagon receptors, may also contribute to the incretin effect, perhaps reconciling findings of low circulating levels of GLP-1 yet substantial meal-stimulated GLP-1R-dependent potentiation of insulin secretion [45, 46]

Always discuss any concerns with our provider before treatment