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J Affect Disord 2024
They have mechanistic plausibility via their effects on central sensitization and neuroinflammation
This prevents toxin recirculation that can slow metabolism or provoke rebound weight gain
Independent lab analysis has found these products contain undeclared ingredients including diuretics, stimulants, and previously-banned weight-loss compounds (sibutramine analogues) and have caused hospitalizations
In support of the latter, the slowing of gastric emptying induced by a mixture of bitter substances (including PTC) was not affected by concurrent administration of GLP-1 and CCK antagonists in mice (55)
