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This GLP-R1 agonist seems to increase oncogenesis in multiple tissues, including the thyroid, bladder, pancreatic, and colorectal [97, 110, 121]

Moreover, depressed patients show a reduction in synaptic density proteins in response to stress (Kang et al., 2012)

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[6] Pharmacodynamic synergy with other carbonic-anhydrase inhibitors (acetazolamide, zonisamide) amplifies the risk of metabolic acidosis and nephrolithiasis, while combined use with valproate has been repeatedly implicated in hyperammonemic encephalopathy even at therapeutic serum valproate levels
