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Tirzepatide for metabolic Dysfunction-Associated steatohepatitis with liver fibrosis
Regeneron has signaled plans to initiate Phase 3 trials, likely in 2027, using its own in-licensed GLP-1/GIP dual agonist (olatorepatide) as the incretin backbone rather than Novo Nordisks semaglutide
Deletion of Dpp4 in hepatocytes lowers portal DPP4 activity and increases portal concentrations of bioactive GLP-1 and GIP
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