glp-1 drugs metformin New aspects of an old drug: as a glucagon-like peptide 1 (GLP-1) enhancer and sensitiser | Diabetologia Metformin and Glucagon-like peptide-1 (GLP-1)

and lower BP

Its no secret that Ozempic is a miracle drug that has changed how patients approach weight loss and other common concerns, such as glucose levels

Matfin G, Van Brunt K, Zimmermann AG, Threlkeld R, Ignaut DA

[1] [3] The pancreas plays a dual role in metabolism: its endocrine cells produce hormones like insulin and glucagon, while exocrine cells secrete digestive enzymes

In the PIONEER 3 trial, similar results were reported showing the superiority of oral semaglutide at 78 weeks (7 mg and 14 mg achieved: 0.7% and 1.1% HbA1c reduction, 2.7 kg and 3.5 kg weight loss) compared to the 100 mg sitagliptin (0.4% HbA1c reduction, 1.1 kg weight loss) in patients with T2DM inadequately controlled with metformin, with or without sulfonylurea

Pharmacological treatment is offered if the symptoms are not managed adequately with lifestyle changes