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The first cohort included female patients who received a semaglutide or tirzepatide prescription during the study period

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This could be due to an additional effect on hepatic glucose production (245)

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Conversely, GLP-1RAs may exert direct effects on the brain, depending on their ability to cross the bloodbrain barrier (BBB)

This delivery method allows the compound to: Enter the bloodstream gradually (NIH) Maintain stable levels over time (NIH) Provide consistent appetite regulation (NIH) For many people, the experience is less about dramatic change and more about subtle recalibration