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[DOI] [PubMed] [Google Scholar] 88.Pratley RE, et al

This means it mimics two different hormones in the body: glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)

Iroegbu et al., 2025)

However, direct comparison against semaglutide 2.4mg is still pending in ongoing trials

Not changing eating habits during treatment If tirzepatide was your entire weight management strategy, meaning you ate whatever you wanted just in smaller amounts because the medication killed your appetite, you have a problem

Importantly, despite their wide-spread usage, patient responses to GLP-1 M are heterogeneous
