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26,27 A Phase II trial in T2D showed a 1% reduction in HbA1c (Diabetes Control and Complications Trial units) and approximately 1.7% body weight reduction over 12 weeks, in comparison to placebo, but a further comparison to an open-label liraglutide active treatment control group was less impressive

How the mighty have fallen: Novo has lost ~$475 billion in value since 2024, when it was worth $650+ billion

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population has ever taken one of these drugs and that approximately 6% of the population is currently taking them

Given the strength of these preliminary signals, the field must now shift focus toward conducting well-powered phase 3 RCTs to validate these associations