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While the risk of initiating TNF- inhibitors (adjusted IRR: 0.56, 95% CI: 0.321.00) and IBD-related surgery (adjusted IRR: 0.79, 95% CI: 0.571.09) was also reduced, these associations were not statistically significant

Kontraindikationen Bei folgenden Erkrankungen ist die Einnahme von GLP-1-Rezeptoragonisten kontraindiziert: Diabetes mellitus Typ 1 oder diabetische Ketoazidose Niereninsuffizienz Akute Pankreatitis Diabetische Gastroparese Alternativen Als alternative Antidiabetika knnen folgende Wirkstoffklassen eingesetzt werden: Insulin(e) Biguanide (Metformin) Sulfonylharnstoffe/Glinide DPP-4-Inhibitoren (Gliptine) SGLT-2-Inhibitoren (Gliflozine) -Glucosidase-Hemmer Hinweise Hypoglykmie Patienten, die einen GLP-1-Rezeptoragonisten in Kombination mit Sulfonylharnstoffen/Gliniden oder Insulin erhalten, knnen ein erhhtes Risiko fr Hypoglykmien haben

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Novel GLP-1-based medications for type 2 diabetes and obesity

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The team initially expected lower GLP-1 levels in those with the variant
