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When bitter compounds activate these receptors in the gut, they stimulate GLP-1 secretion

They used DPP4-targeted immune therapy by vaccines in a C57BL/6J mouse model and were able to show comparable effects like in treatments with gliptins regarding GLP-1 plasma levels and post-prandial glucose excursion and insulin sensitivity in HFD-fed mice

Crucial cytokines including IL-1, IL-6 and TNF- are essential for sustaining the chronic inflammatory state associated with RA [232, 233]

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