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Ileus and intestinal blockage: Obstruction in the intestines that can cause severe pain and require surgical intervention

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Real-World Evidence: Surgery Delivers More than GLP-1s, Sustainably 1

GIP-related neuromodulatory effects have also been proposed, although respiratory-specific evidence remains limited (39, 41)

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Furthermore, GLP-1 and glucose-dependent insulinotropic polypeptides have been shown to induce substance P release from sensory nerves expressing TRPV1 and TRPA1, broadening the potential pain modulation mechanisms of GLP-1 and suggesting their application in peripheral pain management 64