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Exenatide (twice-daily) and lixisenatide are GLP-1 receptor agonists based on exendin-4 that overcome cleavage by DPP-4, however, their half remains short with ~ 24 h due to renal elimination

The majority of patients seeking GLP-1s present with one or more of the following: Insulin resistance or prediabetes PCOS or hormonal dysregulation Thyroid dysfunction Perimenopause-related metabolic changes Metabolic syndrome with multiple cardiovascular risk factors A platform that treats weight as the only relevant variable will miss most of these

What is a GLP-1 agonist, and how does it work