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As semaglutide enters its off patent phase in multiple markets, the implications extend well beyond pricing

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Background Chronic neuroinflammation is increasingly recognized not as a secondary effect but as a primary driver of neurodegenerative disease progression

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Conclusions Once-weekly semaglutide 0.5 mg and 1 mg were considered dominant (more effective and less costly) versus sitagliptin 100 mg and dulaglutide 1.5 mg for the treatment of patients with type 2 diabetes with inadequate glycemic control on oral anti-hyperglycemic medications and are likely to be a good use of healthcare resources in the Spanish setting.

Sulfur burps are a common side effect of GLP-1 medications like semaglutide, caused by slower gastric emptying and bacterial fermentation in the digestive tract