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How tirzepatide interacts with the brain and nervous system Understanding why some people experience anxiety on tirzepatide requires understanding how this medication reaches beyond the gut and pancreas into the brain itself

Gastroenterology 2024;167(2):402404.e3

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Research shows that nearly 90% of people with type 2 diabetes also struggle with their weight, and these medications solve both problems at once

In the ATTAIN-2 trial (participants with obesity and type 2 diabetes), GI adverse event rates were somewhat higher than in ATTAIN-1: nausea 20.1-36.4% versus 8.4% with placebo, vomiting 12.8-23.1% versus 3.8%, diarrhea 21.3-27.4% versus 15.0%, and constipation 17.7-22.4% versus 7.8%