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A post-hoc analysis of SUSTAIN 6 and PIONEER 6 trials identified an emerging cardiovascular signal: MACE risk reduction with semaglutide was numerically stronger in the metformin subgroup (HR 0.70) versus those without metformin (HR 0.86), a directional finding suggesting the combination may carry cardiovascular benefit beyond glycaemic control
As of mid-June 2026 it was a proposal, not a final rule
Individual variation in GLP1R receptor density and sensitivity may influence severity
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The rise is due to the high prevalence of diabetes among the country's population
