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FIDELIO-DKD demonstrated a significant reduction in kidney failure and CV outcomes (HR 0.82 for the primary kidney composite), complemented by FIGARO-DKD and consolidated in the FIDELITY pooled analysis, which showed a 23% reduction in major kidney outcomes and a consistent effect across CKD stages

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This type of diabetes is known as hepatogenous diabetes (HD).6 DM and Cirrhosis Retrospective studies have shown that DM is associated with an increased risk of hepatic complications and death in patients with liver cirrhosis.79 DM is associated with hepatic encephalopathy,10 portal hypertension and bleeding from esophageal varices in decompensated patients.11 In a cohort of individuals with liver infection by HBV, those who developed de novo DM had higher risk of developing cirrhosis and hepatic complications.12 In patients with chronic hepatitis C, DM was an independent predictor of hepatic complications such as ascites, spontaneous bacterial peritonitis, renal dysfunction and hepatocellular cancer.13 DM also has a negative impact on survival of cirrhotic patients