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Starting doses begin at the lower price point, with costs scaling upward as individuals titrate toward their therapeutic maintenance dose

[8] [9] Women of reproductive potential should use non-oral contraceptives or add a barrier method for 4 weeks after initiation and for 4 weeks after each dose escalation

As of May 2026, tirzepatide is only available as a subcutaneous injection

Episode notes were developed by Johns Hopkins internal medicine resident Colin Blumenthal with mentorship from University of Maryland cardiology fellow Karan Desai

As in our study, previous studies have shown that GLP-1RAs increase Nrf2 nuclear translocation and HO-1 expression in these tissues under stressful conditions, thereby increasing oxidative damage