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42 A phase 3 trial including adults with T2DM receiving orforglipron daily (3 mg, 12 mg or 36 mg) showed significant placebo-adjusted reductions in HbA 1c (1.07%) and weight loss (5.9%) at the highest dose

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Cardiovascular outcomes : Semaglutide has demonstrated significant cardiovascular benefits in large randomized controlled trials

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This analysis examines the evidence supporting dual agonism through the clinical development of tirzepatide, focusing on its efficacy, safety profile, and mechanistic rationale

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