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Unlike orlistat, which blocks fat absorption, or phentermine, which is a stimulant-based appetite suppressant, GLP-1 receptor agonists address hunger and satiety at the hormonal level, targeting a fundamental aspect of overeating

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These results suggest that TR might transcriptionally controls the Cyp8b1 expression through a super-enhancer-mediated mechanism

doi: 10.1186/s12933-023-02065-2

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