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Lancet Diabetes Endocrinol 2020;8(2):134149

For users with established metabolic-health goals, indefinite continuation at the effective dose is reasonable, with annual review and re-evaluation of blood markers

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Dual-Hormone Action on Appetite Tirzepatide activates both GLP-1 and GIP receptors in the brain, leading to a stronger reduction in hunger and food cravings than single-agonist drugs

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Clinicians should note that FDA labeling emphasizes the importance of patient education about gastrointestinal side effects and maintaining adequate hydration