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Common adverse events were similar to those reported for selective GLP-1RA, including nausea, vomiting, diarrhea, and constipation, which were more frequent at higher doses

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The SURMOUNT-1 trial demonstrated significant weight loss, with patients losing approximately 15-21% of their body weight at the 15 mg dose over 72 weeks, depending on the statistical method used

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Efficacy and safety of onceweekly semaglutide versus exenatide ER in subjects with type 2 diabetes (SUSTAIN 3): a 56week, openlabel, randomized clinical trial

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