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While many people benefit from 1.5 to 2 litres daily, individual needs vary

Extra caution is important with: Frequent vomiting or suspected cannabinoid hyperemesis Symptoms of gastroparesis, including early fullness, nausea, vomiting, bloating, and upper abdominal pain Diabetes medications that can cause low blood sugar, including insulin or sulfonylureas Heavy cannabis use, high THC products, or unpredictable edibles dosing Prior dehydration, severe constipation, pancreatitis, or unexplained severe abdominal pain Very low appetite, unintended weight loss, or eating disorder history Multiple sedating substances Upcoming surgery, anesthesia, endoscopy, colonoscopy, or gastric emptying testing GLP-1 medications can delay gastric emptying, which also matters for procedures and anesthesia planning

The weight loss curves had not yet plateaued at 48 weeks, suggesting that continued treatment could yield even greater losses

It is thought that individuals with type 2 diabetes have relatively lower levels or effects of incretins like GLP-1

These findings suggest that RETA leads to persistent changes that impair tumor progression even after discontinuing treatment

Prescriptions are arriving from a wider range of providers, including telehealth services and specialized clinics that may operate across multiple jurisdictions