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[DOI] [PubMed] [Google Scholar] 24.Woo JS, Kim W, Ha SJ, et al

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The Combination of Metformin with Morin Alleviates Hepatic Steatosis via Modulating Hepatic Lipid Metabolism, Hepatic Inflammation, Brown Adipose Tissue Thermogenesis, and White Adipose Tissue Browning in High-Fat Diet-Fed Mice

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Phosphorylation at serine 301, within the third intracellular loop of the receptor, is implicated in this PKA-mediated activity, with mutation of this residue abolishing glucose-dependent loss of the receptor from the cell surface

40 Preclinical studies have shown that these effects are mainly mediated trough the effects of GLP-1R activation in the central nervous system (CNS) by the modulation of orexigenic and anorexigenic signaling pathways