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Dotted line indicates time of randomization

Bottom line: At this point, there is no clear evidence that GLP-1 agonists cause depression or suicidal behavior in the average patient, but there are signals that merit caution

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Questions about side effects

Weight loss significantly improves response rates: a 510% weight loss increases the odds of achieving MDA (OR 3.75), with over 10% weight loss raising it further (OR 6.67) [56]

Stop eating at least a few hours before bed to ensure your "tank" is empty before you lie down
