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Understanding how microdosing fits into treatment requires looking at how GLP-1 medications work and how midlife physiology can influence medication response

Minimal clinically important difference on the motor examination part of MDS-UPDRS

It is easier to build a plan while momentum is still positive than after regain has already started

Currently, Wegovy is FDA approved for the following: Children ages 12 years or older with a body mass index (BMI) at or above the 95th percentile for their sex and age Adults with a BMI at or above 30 Adults with a BMI at or above 27 and at least one weight-related health condition, such as heart disease, diabetes, high blood pressure, or sleep apnea Adults with a BMI at or above 27 with established cardiovascular disease and a risk of major adverse cardiovascular events (like heart attack or stroke) Adults with noncirrhotic metabolic dysfunction-associated steatohepatitis (MASH) with moderate to advanced liver fibrosis Note that there are slightly different prescribing rules for Wegovy pills versus Wegovy injections

Retatrutide Name: Retatrutide Manufacturer: Eli Lilly Current stage: Phase III results expected late 2025/2026 Takeaway: If licensed, it could be more effective for weight loss than other GLP-1s

Weekend thoughts: GLP-1 drugs and restaurant stocks This month, I saw two friends I hadnt seen in a few months, and they both look great