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Chest pain , severe shortness of breath, or new irregular heartbeat symptoms

Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth

Native GLP-1, GLP-1RAs and BBB Numerous studies have discovered the expression of native GLP-1 in CNS, implying that natural GLP-1 could cross the BBB from the peripheral circulation via passive transport due to their physiological, molecular biology, pharmacokinetic, and pharmacodynamic properties

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[DOI] [PMC free article] [PubMed] [Google Scholar] 80.Wu H.-Y., Tang X.-Q., Mao X.-F., Wang Y.-X

Similarly, engineering GLP-1 RAs as dual or triple receptor agonists that target additional receptors beyond the GLP-1 receptor may provide greater efficacy in treating obesity by targeting multiple pathways simultaneously