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Systematic Reviews and Meta-analyses One collaborative meta-analysis that synthesized the cardiovascular outcomes reported the results from four studies and 45,568 patients on the add-on therapy modalities [20]

In addition, DPP-4 inhibitors should not be initiated in a patient with a history of pancreatitis

Heart Rhythm

A multivariable logistic regression model following the same principle as the linear models was used to test for a difference in diabetes resolution between treatment arms

Conversely, in another phase 2b study involving patients with T2DM, tirzepatide showed significantly better efficacy in glucose control and weight loss compared to both placebo and dulaglutide, with an acceptable safety and tolerability profile (111)