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10.1038/ijo.2013.120 [DOI] [PubMed] [Google Scholar] 177.O'Neil PM, Birkenfeld AL, McGowan B, Mosenzon O, Pedersen SD, Wharton S, et al

A second survey by benefits consultancy Mercer said 5% of large employers -- which it defines as employing over 500 people -- plan to drop coverage of the drugs in 2027

Clinical studies show no evidence of metabolic acceleration that would offset the natural decline in energy requirements accompanying weight reduction

Those formulations haven't been shown to be safe or effective, the agency said

Important Note on Off-Label Use: Metformin is not FDA-approved for weight loss

A., Kohli, S., Bondy, G