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The dual actions of GLP-1 RAs, namely, the promotion of insulin secretion and the inhibition of glucagon release, exert a significant influence on the plasma ratio of these hormones, thereby contributing to the maintenance of glucose homeostasis in the body

Diabetes and weight-loss trials have shown that the GLP-1 drugs target hormones in the gut and the brain that control appetite and feelings of fullness, cutting down on what's described as food noise, or intrusive thoughts of food

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Abstract Aims/hypothesis The aim of this study was to evaluate the efficacy and safety of oral semaglutide monotherapy vs placebo in a predominantly Chinese population with type 2 diabetes insufficiently controlled with diet and exercise alone