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Why is this question important Taking a step back, conceptually, we expect persons who lose weight, irrespective of the mechanism, to lose both fat mass (FM) and fat free mass (FFM) (persons with obesity generally have higher baseline levels of FFM and SMM than do persons without obesity )

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Therefore, compared to other GLP-1R agonists, exendin-phe1 possesses advantageous pharmacological properties that maximizes insulin secretion

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Acute exercise can alter gut hormone levels, with evidence on GLP-1 being mixedseveral studies show increases in GLP-1 with exercise, while others show minimal changes or decreases

However, discontinuation rates were higher in the orforglipron groups