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The mechanistic rationale for GIPR agonism alongside GLP-1R agonism was initially counterintuitive, given that GIP had been considered therapeutically inert in T2DM due to documented GIP resistance

Divoux A, Tordjman J, Lacasa D, Veyrie N, Hugol D, Aissat A, et al

Correlation between stability of a protein and its dipeptide composition: a novel approach for predicting in vivo stability of a protein from its primary sequence

American Society for Clinical Investigation, DOI 10.1172/jci75276,

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It is worth noting, however, that these clinical trials did not assess the impact of weight loss, including concomitant loss of lean body mass, on individuals physical function, the ultimate measure of patient-relevant outcomes