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In all trials, the treated groups had similar baseline demographics, including age and gender

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Epithelial NAD(+) depletion drives mitochondrial dysfunction and contributes to intestinal inflammation

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Furthermore, cytoplasmic dsDNA levels are significantly increased in FLS from RA patients, causing upregulation of genes such as IL-6 , CXCL10 , TNF- , MMP-13 , IL-1 , and IL-8 via a cGAS-dependent mechanism that also disrupts joint homeostasis [22]

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