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This is the paradox at the heart of a new study

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The UKs MHRA recently issued guidance reminding patients using the GLP-1 agonist tirzepatide, who are also on oral contraceptives, that a barrier form of contraception should also be used.

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Notably, GLP-1RAs benefit pain management through their neuroprotective and metabolic regulatory properties, such as inhibiting inflammation responses and oxidative stress, promoting -endorphin release and modulating several other crucial biological pathways

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