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Chronic Conditions Can Slow Progress: People with type 2 diabetes may lose weight at a slower rate compared to those without

Weight loss trajectory was still accelerating Phase 1 (oral): 10.4-13.1% weight loss at 12 weeks depending on dosing regimen vs 1.2% placebo Phase 2 (T2D): SC amycretin showed up to 14.5% weight loss and HbA1c reductions up to 1.8% at 36 weeks

and (3) the presence of pleiotropic, weight-independent effects

A phenomenon called metabolic adaptation occurs after weight loss, in which your metabolic rate (the number of calories you burn at rest) decreases to a greater extent than expected based on your new weight