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Perros P, McCrimmon RJ, Shaw G, Frier BM

Published endocrinology research describes GLP-1 as involved in appetite-related signaling, insulin secretion pathways, and gastric emptying

[172] The analysis found that individuals using the medications had a slightly higher incidence of neovascular age-related macular degeneration compared to similar individuals not on the medications

In SURMOUNT-5, GI side effects were comparable to semaglutide, although slightly more frequent at higher tirzepatide doses

This gap in evidence means healthcare providers cannot definitively say the drugs are safe or unsafe during breastfeedingonly that the data is insufficient to recommend routine use

Sources Medicines and Healthcare Products Regulatory Agency