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AMPK antagonizes mammalian target of rapamycin (mTOR) activity, and its downstream effector, p27, inhibits cyclin-dependent kinase 2 (CDK2), thereby blocking the G1/S transition in the cell cycle, halting cell division, and subsequently inhibiting cellular proliferation [57]

Berberine is a natural product belonging to a group of alkaloids presents in many medicinal plants

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[DOI] [PubMed] [Google Scholar] 55.Vijiaratnam N, et al
