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BMI 26.5

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The coupling agent used in the reaction can be selected from group consisting of [Ethylcyano (hydroxyimino)acetate)-tri-(l-pyrrolidinyl)-Phosphonium hexa fluorophosphate (PyOxim), ethyl-2 -cyano-2-(hydroxy amino) acetate (Oxyma pure), 0-(benzotriazol-l-yl)-N,N,N,N'- tetramethyluronium tetrafluoroborate (TBTU), diisopropyl carbodiimide (DIC), 1,3- dicyclohexylcabodiimide (DCC) , 0-(7 -azabenzotriazol- 1 -yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate (HATU), 1 -(dimethyl aminopropyl)-3-ethylcarbodiimide hydrochloride (EDC HC1), 0-(benzotriazol-l-yl)-l,l,3,3-tetra methyluronium hexafluorophosphate (HBTU), 1- Hydroxybenzotriazole (HOBt), l-Hydroxy-7-azabenzotriazole (HOAt), Isopropyl chloro formate (IPCF), Benzotriazol-l-yl-oxy-tris(dimethyl-amino)-phosphonium hexa fluorophosphate (BOP), benzotriazole-l-yloxytri(pyrrolidino)phosphonium hexa fluoro phosphate (PyBOP), N,N-bis-(2- oxo-3 -oxazolidinyl)phosphonic dichloride (BOP-C1), bromotri(pyrrolidino)phosphonium hexa fluoro phosphate (PyBrOP), 0-(6-Chloro-l-hydrocibenzotriazol-l-yl)-l,l,3,3-tetramethyl uranium tetra fluoroborate (TCTU), chlorotri (pyrrolidino)phosphonium hexafluorophosphate (PyClOP), Ethyl l,2-dihydro-2-ethoxyquinoline-carboxylate(EEDQ), isobutyl chloro formate (IBCF), 2-succinimido-l,l,3,3-tetramethyluronium tetrafluoroborate(TSTU), l-Cyano-2- ethoxy-2-oxo ethylidene aminooxy) dimethyl amino morpholino-carbeniumhexafluorophosphate (COMU), 2-(5-norbornen-2,3-dicarboximido)-l,l,3,3-tetramethyluronium tetrafluoroborate (TNTU), propane phosphonic acid anhydride (PPAA), 3-(diethoxy phosphoryloxy)-l,2,3- benzotriazin-4(3H)-one (DEPBT) or its mixture

Speaking at a WADA media day in London, Olivier Rabin, WADAs Senior Director of Science and Medicine said that when other substances have been on the monitoring programme in the past, they move from being monitored to being prohibited. One recent example of that process is powerful painkiller Tramadol, which was added to WADAs monitoring list in 2012 and then banned by the UCI in March 2019

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