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S5A-D), indicating that IR D707A/ animals develop severe insulin resistance characterized by dysregulated glucose homeostasis, hyperinsulinemia, and profound lipoatrophy in both sexes

*Correspondence: Alessandra Puddu, [email protected] These authors have contributed equally to this work This article was submitted to Gut Endocrinology, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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For those with reduced appetite, protein sources that are easier to digest, such as eggs, yogurt, or smoothies, may feel more manageable than denser options