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The magnitude of weight loss achieved with GLP-1 RAs often exceeds that seen with lifestyle interventions alone, potentially providing hope for adolescents who have struggled with traditional approaches

Preclinical research in rodent models has consistently demonstrated that GLP-1 receptor activation reduces voluntary alcohol intake, decreases alcohol-seeking behaviour, and attenuates alcohol-induced dopamine release in reward centres of the brain

Meanwhile, there were abundant clinical trial results corresponding to this recommendation of SGLT2i

Ding, B

However, it's also important to be aware that if the medication is stopped, this food noise can return, sometimes intensely

We suggest patients add it to their calendar as a weekly reminder, but frankly, this is not a big challenge because patients are excited to stay on track with their goals, Dr