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doi: 10.1111/dom.12958

[DOI] [PMC free article] [PubMed] [Google Scholar] 131.The Lancet Regional Health-Western Pacific GLP-1 receptor agonists: a magic bullet for obesity

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Comparing the structures of the prokaryotic X-prolyl dipeptidyl aminopeptidase (X-PDAP) from Lactococcus lactis and eukaryotic DPP4 demonstrates that the residues most implicated in X-PDAP activity are conserved in the same positions and orientations of DPP4, despite very different domains flanking the catalytic domain, different dimer organization, and substrate selectivity processes

Of note, an increase in thyroid cancer incidence has been reported with the use of GLP-1RAs in patients with T2D (35)

GLP-1R, liraglutide ameliorated inflammatory injury via activation of P38 MAPK/NF-B signaling pathways [34]