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This study was conducted according to regulatory standards comprising four RI groups (mild, moderate and severe RI, and ESRD), with 10 subjects in each group and a comparable reference group with normal renal function [33, 34]

The extent of weight loss likely also reflects the potency of anti-inflammatory effect, and biomarkers indicative of reduced inflammation have been shown to precede wight loss in multiple trials of this drug class

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Strictures or necrosis were not observed

Central access: 1 gram IV calcium chloride over 10 minutes or slow IV push (peripheral IV administration may be used in cardiac arrest)