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Plasma DPP-4 activity 60 minutes after olive oil gavage ( A , n = 7/group), plasma TG and AUC over 180 minutes ( B , left, n = 2135/group), and plasma levels of active GLP-1 30 minutes before (0 minutes) and 10 minutes after olive oil gavage ( B , right, n = 1215/group) during a lipid tolerance test (LTT) in response to oral gavage of water or a gut-selective (14 g/mouse) or systemic (10 mg/kg) dose of sitagliptin in 16- to 19-week-old WT mice fed a 45% high-fat (HF) diet for 69 weeks

Future studies, especially clinical trials, will be needed to get clearer answers before doctors know how best to use this information

The implication is profound: traditional advertising that taps into cravings and emotional eating no longer functions when the neurological machinery that generates those impulses has been chemically disabled

doi: 10.1186/s12933-023-02065-2

GLP-1, on the other hand, targets the physiological aspects of addiction, making it a complementary addition to behavioral therapies

However, it may cause side effects in some people