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A systematic review ScienceDirect science/article/pii/S2214623724000048 [62] Value of GLP-1 receptor agonists versus long-acting insulins for type 2 diabetes patients with and without established cardiovascular or chronic kidney diseases: A model-based cost-effectiveness analysis using real-world data ScienceDirect science/article/abs/pii/S0168822723001006 [63] GLP-1 receptor agonists: A novel pharmacotherapy for binge eating (Binge eating disorder and bulimia nervosa)

Information last revised January 2026

The mechanism: tirzepatide lowers insulin resistance, and high insulin secretion is regarded as a driver of follicle miniaturization, partly through stronger androgen signaling and more DHT production

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